2 August 2016Pachuca – Olimpia
Referee: Armando Villarreal (USA, photo)
Assistant Referee 1: Corey Parker (USA)
Assistant Referee 2: Frank Anderson (USA)
Fourth Official: Mark Geiger (USA)
Central FC – Whitecaps
Referee: Sherwin Moore (GUY)
Assistant Referee 1: Kevin Stephens (GUY)
Assistant Referee 2: Venton Mars (GUY)
Fourth Official: Ismail Elfath (USA)
3 August 2016
W Connection – Pumas
Referee: Adrian Skeete (BRB)
Assistant Referee 1: Kedlee Powell (JAM)
Assistant Referee 2: Lloyd Edawrds (JAM)
Fourth Official: Leo Clarke (LCA)
Red Bulls – Antigua
Referee: Javier Santos (PUR)
Portland – Dragon
Referee: Jafeth Perea (PAN)
Don Bosco – Monterrey
Referee: Armando Castro (HON)